| | ECDL | | European Computer Driving Licence |
| | eCFR | | Electronic Code of Federal Regulations |
| | ECG | | ElectroCardioGram |
| | ECHASL | | every cloud has a silver lining |
| | ECHASL | | every computer has a software lapse |
| | ECMS | | Electronic Copyright Management System |
| | ECPAT | | End Child Prostitution, Child Pornography and Trafficking of Children for Sexual Purposes |
| | ECT | | electroconvulsive therapy |
| | EDACS | | Enhance Digital Access Communication System |
| | EDF | | Extended Depth of Field |
| | EDGE | | Enhanced Data-Rates for GSM Evolution |
| | EDI | | Electronic Data Interface |
| | EDI | | Electronic Document Interchange |
| | EDOC | | Effective Date of Contract |
| | EDOC | | Enterprise Distributed Object Computing |
| | EDP | | Emotionally Disturbed Person |
| | EDRM | | electronic document and records management |
| | EDRMS | | Enterprise Document and. Records Management System |
| | EDT | | Eastern Daylight Time |
| | EDT | | Eastern Daylight Time (Gmt -400) |
| | EDT | | Estimated Departure TIme |
| | EEG | | Electroencephalogram |
| | EEOC | | Equal Employment Opportunity Commission |
| | EEPROM | | electrically erasable programmable read-only memory |
| | EEPROM | | Electronically Erasable Programmable Read Only Memory |
| | EEROM | | Electrically Eraseable Read Only Memory |
| | EFI | | Electronic Fuel Injection |
| | EFM | | Ethernet in the First Mile |
| | EFN | | Enough For Now |
| | EFT | | Electronic Funds Transfer |
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