| | sar | | Smart Ass Remark |
| | sar | | Specific Absorption Rate |
| | SARG | | Search ARGument |
| | SARS | | Severe Acute Respiratory Syndrome |
| | sas | | Smiling , Always Smiling |
| | sas | | Special Air Service |
| | sas | | special ass sex |
| | SASA | | straight-acting, straight-appearing |
| | SASB | | Sobbing And Sniffing Bitterly |
| | SASE | | Self Addressed, Stamped Envelope |
| | SASE | | Self Addressed Stamped Envelope |
| | sass | | Short Attention Span Syndrome |
| | sat | | scholastic aptitude test |
| | sat | | Scholastic Assessment Test |
| | sat | | SIM Application Toolkit |
| | SATC | | Sex And The City |
| | SAU | | Same As Usual |
| | SAU | | sheep |
| | sayor | | speak at your own risk |
| | sb | | Smile Back |
| | sb | | Smiles Back |
| | sb | | somebody |
| | SBB | | Stupid Beyond Belief |
| | sbcn | | sitting behind the computer, naked |
| | SBCS | | single-byte character set |
| | SBD | | Silent But Deadly |
| | SBF | | Single Black Female |
| | SBH | | Straight Black Hair |
| | SBID | | shitty but it'll do |
| | SBID | | sometime before i die |
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