| SMSL | | Standard Multimedia Scripting Language |
| SMSMDS | | Surface Missile System Maintenance Data System |
| SMTN | | Something More Than Nothing |
| SMTP | | Simple Mail Transfer Protocol |
| SMWF | | Seamless Wi-Fi |
| sn2d | | Stay No to Drugs |
| snac | | Sitting Naked At Computer |
| snac | | snack |
| SNAG | | Sensitive New Age Guy |
| SNAG | | Sensitive new-age guy |
| SNAT | | source network address translation |
| SNERTS | | snot-nosed egotistical rude teenager |
| SNERTS | | snot-nosed egotistical rude twits |
| SNL | | Saturday Night Live |
| SNM | | Say No More |
| SNMP | | Simple Network Managment Protocol |
| sntd | | Stay No to Drugs |
| SOA | | same old architecture |
| SOA | | Service Oriented Architecture |
| SOA | | service-oriented architecture |
| SOAG | | Son Of A Gun |
| SOAP | | Simple Object Access Protocol |
| SOBOE | | Shortness of Breath on Exertion |
| SOCLMAO | | Spit on my computer laughing my ass off |
| SOCOM | | Special Operations COMmand |
| SOD | | Season of Death |
| SOD | | Society of d**kheads |
| SOD | | Stupidity of the Day |
| SOFL | | School of Foreign Languages |
| SOFL | | Sitting On the Floor Laughing |
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