| SRSCM | | Supplement Restraint System Control Module |
| SS7 | | Signalling System 7 |
| SSADM | | Structured systems analysis and design |
| SSBN | | Ship Submersible Ballistic Nuclear |
| sscwt | | superannuation contribution withholding tax |
| ssdd | | same sh*t different day |
| ssdd | | same sh*t different day |
| SSEWBA | | Someday Soon, Everything Will Be Acronyms |
| SSFD | | Solid State Disk |
| SSI | | subject says it |
| SSID | | service set identifier |
| SSINF | | So stupid it's not funny |
| SSL | | secure socket layer |
| SSL | | secure sockets layer |
| SSL | | sorry so late |
| SSL | | sorry so long |
| SSML | | speech synthesis mark-up language |
| SSPI | | Security Support Provider Interface |
| SSRS | | SQL Server Reporting Services |
| sstb | | So Sad, Too Bad |
| ssw | | South-southwest |
| SSWA | | So Say We All |
| sswly | | South-southwesterly |
| sswrn | | South-southwestern |
| sswwd | | South-southwestward |
| ST-DS9 | | Star Trek Deep Space Nine |
| ST-TNG | | Star Trek The Next Generation |
| stasap | | Sooner Than As Soon As Possible |
| stbbf | | soon to be boyfriend |
| STBID | | Some Time Before I Die |
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